What is Concussion
• Memory loss
• Depression
• Aggression
• Dementia
• Suicidal thoughts
• Early death
We need to understand and prove up an effective treatment.
Post-concussion syndrome (PCS) is a condition that can occur following a mild traumatic brain injury (mTBI), commonly known as a concussion. It is characterized by a range of symptoms that persist for an extended period after the initial injury. Here is a comprehensive outline of PCS based on the information from the BreatheHope Knowledge Base:
Symptoms of PCS:
- Headache: Persistent or recurrent headaches are a common symptom of PCS.
- Dizziness: Feeling dizzy or lightheaded can be prevalent in individuals with PCS.
- Neuropsychiatric Symptoms: These may include mood changes, anxiety, depression, irritability, and emotional instability.
- Cognitive Impairments: Deficiencies in cognitive functions such as memory, attention, processing speed, and executive functions are often observed.
Duration of Symptoms:
- PCS symptoms typically persist for weeks or months after the initial injury.
- Approximately 25% of individuals with PCS may experience prolonged PCS (PPCS), where symptoms last for over six months.
Impact on Daily Life:
- Individuals with PCS, especially those with PPCS, are at high risk for emotional and cognitive dysfunction.
- These impairments can lead to difficulties in carrying out daily activities, work responsibilities, and maintaining social relationships.
Associated Brain Pathology:
- Diffuse Axonal Injury: A common pathological feature of mTBI (mild Traumatic Brain Injury) involving shearing axonal pathways and small blood vessels.
- Brain Contusions: Direct hits to the skull can cause brain contusions, often affecting the frontal and anterior temporal lobes.
Secondary Pathologies Include ischemia, mild edema, and inflammatory processes that lead to impaired regenerative/healing processes due to tissue hypoxia.
Diagnosis of PCS:
- Diagnoses of TBI/PCS are confirmed through clinical interviews, symptom lists, and specific questionnaires, such as the Rivermead Post Concussion Symptoms Questionnaire.
- Diagnostic criteria such as the PTSD Checklist-Military and DSM-IV criteria are also utilized for accurate diagnoses.
Treatment and Research:
- Hyperbaric Oxygen Therapy (HBOT) has shown promise in improving outcomes for individuals with PCS.
- Ongoing research aims to explore HBOT’s effectiveness in reducing symptoms, enhancing recovery, and offering therapeutic benefits for patients with PCS and related conditions.
- BreatheHope is funding this research.

